Preparation of .BETA.-lactams from Optically Active Isocyanate and Vinyl Ethers under High Pressure.
نویسندگان
چکیده
منابع مشابه
Stereoselective synthesis of optically active beta-lactams, potential inhibitors of pilus assembly in pathogenic bacteria.
[reaction: see text] Optically active beta-lactams 3 are obtained in excellent yields (up to 93%) and with complete stereoselectivity from Meldrum's acid derivatives 1 and Delta(2)-thiazolines 2. A selective reduction to aldehydes 5 (R = Ar or CH(2)Ar) was then accomplished by using DIBAL-H. This rigid framework, with stereochemistry different than that of penicillin, is designed to be a suitab...
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ژورنال
عنوان ژورنال: THE REVIEW OF HIGH PRESSURE SCIENCE AND TECHNOLOGY
سال: 1998
ISSN: 0917-639X,1348-1940
DOI: 10.4131/jshpreview.7.1408